How Long Does Retinol Take To Get Rid Of Wrinkles?

How Long Does Retinol Take To Get Rid Of Wrinkles?

Many people ask how to get rid of wrinkles fast- and the answer is always – RETINOIDS. But how long do retinoids take to improve wrinkles? Before we discuss how long it takes to see results from retinol, let's discuss nomenclature. Retinol is a type of retinoid.1 There are prescription and cosmetic retinoids. Retinol is found in cosmetic products, adapalene is in over-the-counter products while tretinoin, adapalene, tazarotene and trifarotene are found in prescription products. The only retinoids FDA approved to treat wrinkles are tretinoin and tazarotene. However, studies have shown that retinol is effective on wrinkles.2 This blog will review the peer-reviewed evidence-based data on using retinol and retinoids for wrinkles.

How Soon Can Changes In Skin From Retinoids Be Seen With A Microscope?

In a study3 comparing tretinoin 0.1% and retinol 0.1%, both retinoids showed skin improvement under the microscope at 4 weeks. However, it usually takes at least 12- 24 weeks to see skin changes without a microscope.

How Fast Can Retinol Improve Wrinkles?

Studies have shown that retinol improves wrinkles. Retinol 0.1% was shown to improve crow’s feet lines by 44% at 52 weeks (one year).4 How fast wrinkles improve depends on the potency, frequency and amount of retinoid used.

You do not want to start a strong retinoid too quickly because it can lead to retinoid side effects. Remember that prescription retinoids are stronger than retinol so you will see results faster with prescription retinoids. However, we advise you to first begin a low-strength retinol and work your way up slowly to a stronger retinol and then convert over to a prescription strength retinoid. Click here to see how to use retinoids.

Which Retinoid Cream Improves Wrinkles The Fastest?

In 2001, a study compared 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams and tretinoin 0.05% cream.5 These were applied every night for 24 weeks. All of the percentages of tazarotene and the 0.05% tretinoin improved fine wrinkles and evened skin tone. Tazarotene 0.1% worked the best at 8, 12, and 20 weeks but had a higher rate of side effects. However, by 24 weeks, tretinoin 0.05% and tazarotene 0.1% had similar efficacy. This study shows that wrinkles improve the fastest with tazarotene 0.1% as compared to tretinoin 0.05% and lower doses of tazarotene.

How Long Does Retinol Take To Get Rid Of Wrinkles?

Studies showing how fast prescription retinoids improve wrinkles:

How Fast Does Tretinoin Improve Wrinkles?

Most people who use tretinoin see improvement of wrinkles by 24 weeks.6 A higher percent of tretinoin (0.1%) has faster improvement of wrinkles as compared to a tretinoin strength of 0.05%.

Higher-strength tretinoin improves wrinkles faster than low doses do, however, with time, they both improve wrinkles the same. A 1995 study compared wrinkle improvement placebo cream vs tretinoin 0.025% cream vs tretinoin 0.1%.7 As expected, the 0.025% cream was associated with fewer side effects than the 0.1% tretinoin. At 48 weeks, the improvement of wrinkles was the same (there was no statistical difference) for both doses of tretinoin- showing that lower strength retinoids will have the same improvement as the higher strength ones with time.

Do Stronger Retinoids Improve Wrinkles Faster?

Higher percentages of retinoids improve wrinkles faster, so if you want to get rid of wrinkles quickly, a stronger retinoid is the way to go but be prepared to have more side effects. Many studies have shown that weaker retinoids take longer to see results, but have fewer side effects.8

 One study of tretinoin emollient cream for 48 weeks compared two groups: the first group used tretinoin 0.05% and the other group used tretinoin 0.01%. At 24 weeks, more improvement was seen in the 0.05% group as expected because this was a more potent form of retinoid. The 0.01% group showed less improvement at 24 weeks but continued to improve from weeks 24- 48. By 48 weeks, the lower dose group still did not achieve the levels of improvement observed with the stronger 0.05% formulation. These results demonstrate that higher doses yield a faster and better response at 48 weeks, but lower doses do cause improvement in wrinkles and skin appearance.

How Fast Does Tazarotene Improve Wrinkles?

Studies have shown that tazarotene 0.1% is the most effective antiaging retinoid. It was approved by the FDA in 19979 to improve the appearance of fine facial wrinkles and uneven skin tone. Results may be seen as early as 8 weeks.10 One study of tazarotene 0.1% gel ( compared to placebo) used on the arms showed improvement of wrinkles and skin texture at 12 weeks.11 A summary of research trials using tazarotene for wrinkles can be found in this reference.12

In summary- the higher a retinoid percentage is- the faster wrinkles and fine lines will go away but more side effects will be seen. Retinoid side effects can lead to inflammation and pigmentation. Inflammation is a cause of skin aging and an uneven skin tone is undesirable. For this reason- we recommend starting with a low strength retinoid and slowly working your way up to the strongest retinoid that you can tolerate without getting skin inflammation.

References

  1. Baumann L. Ch 45 Retinoids in Cosmetic Dermatology (McGraw Hill 222) 3rd edition.
  2. Kafi, R., Kwak, H. S. R., Schumacher, W. E., Cho, S., Hanft, V. N., Hamilton, T. A., ... & Kang, S. (2007). Improvement of naturally aged skin with vitamin A (retinol). Archives of dermatology, 143(5), 606-612.
  3. Kong R, Cui Y, Fisher GJ, Wang X, Chen Y, Schneider LM, et al. A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin. J Cosmet Dermatol. 2016;15(1):49-57.
  4. Randhawa, M., Rossetti, D., Leyden, J. J., Fantasia, J., Zeichner, J., Cula, G. O., ... & Tucker-Samaras, S. (2015). One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial. Journal of drugs in dermatology: JDD, 14(3), 271-280.
  5. Kang S, Leyden JJ, Lowe NJ, Ortonne JP, Phillips TJ, Weinstein GD, et al. Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks. Arch Dermatol. 2001;137(12):1597-604.
  6. Olsen EA, Katz HI, Levine N, Nigra TP, Pochi PE, Savin RC, et al. Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications. J Am Acad Dermatol. 1997;37(2 Pt 1):227-30.
  7. Griffiths CE, Kang S, Ellis CN, Kim KJ, Finkel LJ, Ortiz-Ferrer LC, et al. Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams. Arch Dermatol. 1995;131(9):1037-44.
  8. Olsen EA, Katz HI, Levine N, Nigra TP, Pochi PE, Savin RC, et al. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol. 1997;37(2 Pt 1):217-26.
  9. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021184s009lbl.pdf
  10. Kang S, Leyden JJ, Lowe NJ, Ortonne JP, Phillips TJ, Weinstein GD, et al. Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks. Arch Dermatol. 2001;137(12):1597-604.
  11. Sefton, J., Kligman, A. M., Kopper, S. C., Lue, J. C., & Gibson, J. R. (2000). Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel. Journal of the American Academy of Dermatology, 43(4), 656-663.
  12. Ogden, S., Samuel, M., & Griffiths, C. E. (2008). A review of tazarotene in the treatment of photodamaged skin. Clinical interventions in aging, 3(1), 71. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544371/

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