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HA Immerse Serum
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Nothing in this product works against any of your four letters, so it is safe for your skin type.
Not recommended for your sensitivity
Alastin HA Immerse Serum ranks among the best HA serums, featuring large-molecular-weight hyaluronic acid for exceptional hydration and soothing benefits.
- Deeply hydrates and plumps skin
- Softens fine lines and wrinkles
- Unlike any other HA serum
Why Dr. Baumann carries this
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Approved for Baumann Skin Types
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
Approved for 8 of the 16 Baumann Skin Types, and not for the Allergic sensitive subtype. Dr. Baumann reviews every product against all 16 types before it goes on the site.
What it is and what it does
Enjoy a glowing, dewy complexion with the award-winning Alastin HA Immerse Serum, a top-selling hyaluronic acid serum that quenches and revitalizes skin instantly.
Dermatologist-recommended for its ability to provide both immediate and long-term hydration, this serum smooths and plumps your skin for a radiant, glass finish.
Its unique formula features high-molecular-weight hyaluronic acid, a powerful humectant that delivers a soothing, deeply hydrating effect while helping to reduce the appearance of fine lines and wrinkles. Powered by unique and fascinating peptides, it stimulates your skin’s natural production of hyaluronic acid, ensuring lasting anti-aging benefits.
Perfect for daily use and safe to use several times a day to keep skin glowing.
This consistently top-rated serum is praised for its ability to restore moisture and visibly improve the skin’s texture, leaving it soft, smooth, and radiant.
Ideal for dry, oily, aging, or sensitive skin types.
Free of parabens, fragrance, and formaldehyde
Who it is for
- Deeply hydrates and plumps skin
- Softens fine lines and wrinkles
- Unlike any other HA serum
- Boosts natural hyaluronic acid production
- Soothes with large molecular weight HA
- Enhances results from dermal fillers
- Hides retinoid flakiness
Approved for 8 of the 16 Baumann Skin Types, and not for the Allergic sensitive subtype.
Key ingredients

Attracts water, giving cells and skin volume. Plays a key role in cell signals and other vital processes. It cushions the skin, providing resilience and firmness. This moisturizing humectant temporarily plumps fine lines and wrinkles. HA makes skin feel dewy and look radiant and glowing. Great for oily skin because it feels lightweight and non-greasy on the skin. Safe for all skin types. HA helps other skincare products get into the skin. This antiaging and hydrating ingredient can radically alter how your skin routine works by affecting penetration and absorption of other ingredients- so make sure you use it in the correct step of your skin care routine.

Hexapeptide-11
Hexapeptide-11, is a bioactive peptide with a molecular weight of 889.04 Daltons. It upregulates Hyaluronan Synthase 2 (HAS2), boosting hyaluronic acid (HA) production to improve skin hydration and elasticity. Simultaneously, it downregulates Hylauronidase 2 (HYAL2), preventing HA degradation and enhancing skin moisture retention. Hexapeptide-11 promotes autophagy, a process that removes damaged cells and recycles cellular components. This assists macrophages in clearing debris, such as damaged cells and red blood cell remnants after injury or bruising, which accelerates healing, reduces inflammation, and helps combat cellular senescence- a known cause of aging.. Hex11 also upregulates the early growth response 3 (EGR3) gene, crucial for strengthening the skin barrier by enhancing keratinocyte function. Moreover, Hexapeptide-11 is linked to increased collagen production, which aids in skin repair and rejuvenation, making it popular in antiaging skin care.

Octapeptide-45, a synthetic peptide, is notable for stimulating hyaluronic acid (HA) production in the skin. It upregulates the HAS2 enzyme, which boosts dermal fibroblast activity, leading to the synthesis of large, high molecular weight HA molecules. These molecules offer enhanced hydration, are less prone to degradation, and promote skin regeneration. By fostering an anti-inflammatory environment, Octapeptide-45 helps reduce redness and irritation, making it particularly beneficial for sensitive or rosacea-prone skin. It delivers anti-aging benefits through improved moisture retention and skin elasticity, soothing stressed skin while enhancing resilience.

Tremella Fuciformis Sporocarp Extract
Tremella Fuciformis Sporocarp Extract), also known as Snow Mushroom Extract, is a natural ingredient derived from an edible mushroom. It is high in polysaccharides and renowned for its exceptional ability to enhance skin hydration, holding up to 500 times its weight in water, similar to hyaluronic acid. This extract supports the skin’s natural hyaluronic acid production, improving moisture retention and strengthening the skin barrier, making it valuable for barrier repair. Additionally, it has antioxidant properties that protect the skin from free radical damage and environmental stress and mild anti-inflammatory effects, soothing irritated or sensitive skin.

Lactoferrin
Lactoferrin is known for its iron-binding properties, lactoferrin enhances macrophage function, speeding up the breakdown of blood byproducts. It also promotes tissue repair and supports hyaluronic acid production for better hydration and skin recovery.

Peptides are a diverse group of ingredients, each offering unique benefits, such as boosting collagen production, firming skin, or improving texture by coating the skin's surface. However, peptides can inactivate other ingredients, so it's crucial to use peptide-based products in the correct step of your skincare routine and ensure all ingredients are compatible. Since peptides often struggle to penetrate the skin, they work best in a routine specifically designed to enhance their absorption. To maximize their effectiveness, your entire skincare regimen should focus on optimizing penetration, maintaining stability, and minimizing reactions with incompatible ingredients.

Glycerin (Glycerol) is the best natural moisturizing ingredient to hydrate skin quickly. May give products a sticky feel.

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, also known as SYN®-HYCAN, is a peptide that increases hyaluronic acid (HA) synthesis within the skin. By boosting HA production, it helps the skin retain more moisture, adding volume and making it appear plumper. Increasing HA within the extracellular matrix (ECM) facilitates signaling that can lead to fibroblast functionality such as collagen production. This plumps skin volume, firms skin, decreases laxity and reduces sagging. It hydrates and strengthens the skin structure, contributing to a smoother, more youthful complexion.

Xylitol
Xylitol, a saccharide derived from natural sources such as birch trees or corn cobs, is a humectant with moisturizing properties. It works by attracting moisture into the skin, helping to maintain hydration levels. Xylitol is used in skincare for its ability to combat skin dehydration and enhance skin barrier function by promoting lipid production. Xylitol’s anti-inflammatory benefits stem from its ability to modulate immune responses by lowering pro-inflammatory cytokine production, These actions help reduce inflammation and protect against external irritants.

Propanediol
Propanediol, a glycol derived from corn sugar or synthetic processes, is a humectant and solvent with moisturizing properties. It works by drawing moisture into the skin, improving hydration levels. Propanediol is a penetration enhancer that increases absorption of other ingredients in the skin care routine. It is a natural alternative to propylene glycol, offering similar benefits with less irritation. Use to improve the texture and stability of formulations, resulting in enhanced product performance and increased shelf life.

Phospholipids
Phospholipids are essential for maintaining the skin barrier by forming protective bilayers that prevent moisture loss and shield against irritants. In skincare, they enhance hydration, repair the lipid barrier, and improve ingredient delivery. Their fatty acid components help restore the skin’s lipid barrier, aiding in moisture retention. Examples include Phosphatidylcholine, which restores lipid content, and Lecithin, an emollient that smooths and hydrates the skin for better barrier function.

Phosphatidylserine
Phosphatidylserine is a phospholipid that plays a key role in cell signaling. It helps signal macrophages to target and eliminate damaged red blood cells (RBCs), facilitating the removal of cellular debris and promoting faster bruise clearance. This enhanced macrophage activity aids in reducing the appearance of bruises and accelerates skin recovery after trauma. Phosphatidylserine also has antioxidant and anti-inflammatory properties, protecting skin cells from oxidative stress and environmental damage. Additionally, it strengthens the skin barrier by integrating into the lipid bilayer of cell membranes, enhancing lipid organization and stability, which prevents moisture loss and shields against irritants.

Dermatologist-recommended antioxidant for antiaging because it increases collagen and prevents melanin production. Protects skin from sun exposure and lightens dark spots.

An antioxidant and hydrating ingredient. Stabilizes Vitamin C.

Caprylic/Capric Triglyceride
Combination of hydrating coconut oil and glycerin to moisturize skin.
Full ingredient list
Product type and skin type data
| Brand | Alastin |
|---|---|
| Product type | Facial Moisturizer |
| Size | 1 oz. |
| Item number | ALA-552 |
| Approved Baumann Skin Types | OSPW, OSPT, ORPT, ORNT, OSNW, OSNT, ORPW, ORNW |
| Recommended for these sensitivities | Acne, Redness, Stinging |
Read more from Dr. Baumann
Skincare LibraryBy Dr. Leslie Baumann · 6 min read
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Questions about this product
Answered by Dr. Leslie Baumann, MD, FAAD · Miami, FL · 200+ partner practices
Alastin HA Immerse Serum is a favorite among many
dermatologists because it uses large-molecular-weight hyaluronic acid for a
more soothing, surface-hydrating effect. It also contains advanced ingredients
like Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate and
Octapeptide-45, which enhance your skin’s natural HA production. These make it
one of the best and most effective HA serums, delivering both immediate and
long-term benefits. It’s truly worth splurging on for those seeking serious hydration
and plumping results.
Yes, the serum contains humectants, HA, and peptides that
not only hydrate but also plump the skin, reducing the appearance of fine lines
within minutes of application.
To address flaking, dermatologists recommend using a gentle
exfoliant first, followed Alastin HA Immerse Serum. The serum’s deep hydration
helps smooth and soothe the skin, reducing dryness and peeling caused by
retinoids.
Users typically notice immediate hydration, but this is
temporary and lasts about 24 hours. Long lasting improvements in skin texture
and plumpness are seen after 2-4 weeks of regular use.
Yes, Alastin HA Immerse Serum works well layered under
moisturizers, SPF, or makeup to lock in hydration without pilling. It also
enhances absorption because it contains penetration enhancers, allowing active
ingredients to penetrate more effectively.
Alastin HA Immerse Serum is lightweight, making it suitable
for oily skin. If you have very oily skin, you can even use it as your sole
moisturizer in place of cream.
If you're prone to clogged pores, this serum contains
dimethicone and caprylic/capric triglyceride, which are mildly comedogenic for
some individuals. It's best to test on a small area for a few days to see if it
causes blackheads or milia. Your skin's response may vary based on your skin
type and the other products in your routine. Using it alongside a retinoid,
like retinol, can help prevent clogged pores.
Absolutely, it was developed by a plastic surgeon to soothe
and hydrate skin after treatments like microneedling or chemical peels, helping
to speed up recovery and maintain hydration.
You should use it at least once a day. Very dry skin types
in dry environments may benefit from using it 2-4 times a day. There is no
limit to how much you can apply this gentle serum, and it has additive effects
with more frequent use.
Many users love using Alastin HA Immerse Serum under foundation or concealer to prevent
flaking, especially when their skin is dry or peeling from retinoids.
Yes, it is fragrance-free, making it ideal for sensitive
skin.
Yes, Alastin HA Immerse Serum is perfect to soothe skin that
has retinoid dermatitis from beginning retinol or tretinoin. Apply this serum
first and cover with a soothing oil like Argan oil to treat skin irritated red,
or peeling from retinoids.
Can I use this on skin that is over-exfoliated from too many
exfoliants?
Yes, Alastin HA Immerse Serum is ideal for soothing skin that has been
over-exfoliated from excessive use of exfoliants. Its high-molecular-weight
hyaluronic acid provides deep hydration, helping to calm and repair irritated,
red, or peeling skin. Apply the serum first, then follow with a soothing occlusive,
such as squalane or argan oil, to lock in hydration and aid recovery.
Can I use this on skin abrasions like rug burn?
Yes, Alastin HA Immerse Serum is great for soothing and hydrating skin with
abrasions such as rug burn, chafing, and friction burns. The serum's
large-molecular-weight hyaluronic acid provides deep hydration, while peptides
aid the skin’s natural healing process. Apply it to the affected area and
follow with a gentle moisturizer or balm to lock in moisture and support skin
recovery.
Reviews
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