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BIO SERUM FIRM Rejuvenating Growth Factor and Peptide Treatment
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Nothing in this product works against any of your four letters, so it is safe for your skin type.
Not recommended for your sensitivity
Serum to Prevent Wrinkles and Sagging
- Helps block the aging protein progerin
- Prevents loss of elasticity
- Has many humectants
Why Dr. Baumann carries this
Written for this product
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Approved for Baumann Skin Types
- 3
- 4
- 7
- 8
- 11
- 12
- 15
- 16
Approved for 8 of the 16 Baumann Skin Types. Dr. Baumann reviews every product against all 16 types before it goes on the site.
What it is and what it does
Tired of fine lines and wrinkles and looking for a serum to prevent skin sagging? Neocutis BIO SERUM FIRM is the rejuvenating treatment dermatologists trust to deliver visible results. This powerful anti-aging serum benefits your skin by reducing the appearance of fine lines and wrinkles, promoting a firmer, more youthful complexion.
As a cutting-edge growth factor and peptide serum, this anti-wrinkle treatment harnesses the power of advanced skincare science to rejuvenate your skin. The unique blend of growth factors and progeline work synergistically to support skin's natural collagen production, improving firmness and strength. Reviews praise its silky texture and quick absorption, leaving your skin feeling nourished without any greasy residue.
Two of the star ingredients, human growth factors isolated from the cutaneous lysate of fibroblasts and a blend of proprietary peptides such as Trifluoroacetyl Tripeptide-2 provide numerous antiaging and sagging prevention benefits.
Suitable for wrinkle-prone skin types, including sensitive and mature skin, Neocutis BIO SERUM FIRM is the ultimate solution for anyone seeking a hyaluronic acid serum that actually has long term benefits. If you have dry skin, consider Neocutis BIO CREAM FIRM RICHE instead.
This rejuvenating serum is non-comedogenic, paraben-free, formaldehyde-free and fragrance-free, making it a safe and effective choice for daily use.
Who it is for
- Helps block the aging protein progerin
- Prevents loss of elasticity
- Has many humectants
Approved for 8 of the 16 Baumann Skin Types.
Key ingredients

This ingredient is extracts from cells. How this ingredient works depends upon what types of cells it comes from. In Neocutis products, this lysate has been extracted from skin fibroblasts. It contains Processed Skin Cell Proteins (PSPs). This lysate has many antiaging growth factors and cytokines.

Progeline, also known as Trifluoroacetyl Tripeptide-2, is a synthetic peptide used in anti-aging skincare products. It works by inhibiting the production of progerin, a protein that accelerates skin aging. By reducing progerin levels, Progeline helps preserve skin elasticity and firmness, reducing wrinkles and sagging. This peptide is commonly found in high-end serums and creams aimed at maintaining a youthful appearance.

Peptides are a diverse group of ingredients, each offering unique benefits, such as boosting collagen production, firming skin, or improving texture by coating the skin's surface. However, peptides can inactivate other ingredients, so it's crucial to use peptide-based products in the correct step of your skincare routine and ensure all ingredients are compatible. Since peptides often struggle to penetrate the skin, they work best in a routine specifically designed to enhance their absorption. To maximize their effectiveness, your entire skincare regimen should focus on optimizing penetration, maintaining stability, and minimizing reactions with incompatible ingredients.

Acetyl Glucosamine
Acetyl Glucosamine is a type of sugar (saccharide) that helps make glycosaminoglycans like hyaluronic acid which keep skin hydrated, and reduce wrinkles. It also helps suppress the production of melanin, the pigment that causes dark spots, making it useful for treating uneven skin tone. Additionally, it has soothing anti-inflammatory effects. it is a humectant.

Dermatologist-recommended antioxidant for antiaging because it increases collagen and prevents melanin production. Protects skin from sun exposure and lightens dark spots.

Attracts water, giving cells and skin volume. Plays a key role in cell signals and other vital processes. It cushions the skin, providing resilience and firmness. This moisturizing humectant temporarily plumps fine lines and wrinkles. HA makes skin feel dewy and look radiant and glowing. Great for oily skin because it feels lightweight and non-greasy on the skin. Safe for all skin types. HA helps other skincare products get into the skin. This antiaging and hydrating ingredient can radically alter how your skin routine works by affecting penetration and absorption of other ingredients- so make sure you use it in the correct step of your skin care routine.

Hydrogenated face oil that is more stable than squalene found in sebum.

Caprylic/Capric Triglyceride
Combination of hydrating coconut oil and glycerin to moisturize skin.

Glycerin (Glycerol) is the best natural moisturizing ingredient to hydrate skin quickly. May give products a sticky feel.
Full ingredient list
Product type and skin type data
| Brand | Neocutis |
|---|---|
| Product type | Facial Moisturizer |
| Size | 30 ML |
| Item number | NC-2801643 |
| Approved Baumann Skin Types | OSPW, OSNW, DSPW, DSNW, DRPW, ORPW, ORNW, DRNW |
| Recommended for these sensitivities | Acne, Redness, Stinging |
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Questions about this product
Answered by Dr. Leslie Baumann, MD, FAAD · Miami, FL · 200+ partner practices
Yes this serum is worth splurging on because it contains fibroblast derived growth factors and processed skin proteins that are unique to the Neo Cutis brand.
Tetrapeptide-21: This peptide helps to stimulate collagen production, enhancing skin firmness and reducing the appearance of fine lines and wrinkles. Palmitoyl Tripeptide-1 Acetate: This peptide promotes skin repair and renewal by mimicking the body's natural repair processes. It boosts collagen synthesis, helping to smooth wrinkles and firm the skin.Trifluoroacetyl Tripeptide-2: Known for its anti-aging properties, this peptide targets progerin, a protein associated with aging, to help delay visible signs of aging. It works to improve skin firmness and elasticity, contributing to a more youthful appearance.
Processed Skin Proteins (PSP) are good for mature skin because they contain a rich blend of growth factors, cytokines, and interleukins, which are essential for skin repair and rejuvenation. These proteins help to stimulate collagen production, support cell turnover, and improve overall skin health.
Reviews
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