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HYALIS+ Intensive Hydrating Serum
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Nothing in this product works against any of your four letters, so it is safe for your skin type.
Not recommended for your sensitivity
Hydrating Humectant Serum
- Provides instant dewy radiance
- Smooths and conceals retinoid-induced flakiness
Why Dr. Baumann carries this
Written for this product
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Approved for Baumann Skin Types
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
Approved for 8 of the 16 Baumann Skin Types. Dr. Baumann reviews every product against all 16 types before it goes on the site.
What it is and what it does
Experience deep hydration and smoother, more supple skin with Neocutis HYALIS+ Intensive Hydrating Serum. This is the most popular of the "baby foreskin face creams". This oil-free intensely hydrating serum is expertly formulated with multiple types of pure hyaluronic acid (HA) to boost HA levels in skin. This luxury hyaluronic acid serum delivers intense moisture to rapidly hydrate and smooth away fine lines and wrinkles.
To further boost HA levels, Sodium Polyglutamate counteracts HA-degrading enzymes, while Acetyl Glucosamine stimulates hyaluronic acid production within the skin, promoting instantly plumper, more hydrated, glowing skin.
Perfect for soothing and replenishing stressed skin, especially after cosmetic procedures or dermatological treatments, this dermatologist-tested serum is non-comedogenic, free of color additives and fragrances, and never tested on animals.
Transform your skincare routine with Neocutis HYALIS+ Intensive Hydrating Serum, the ultimate solution for achieving soft, smooth, and hydrated skin.
Who it is for
- Provides instant dewy radiance
- Smooths and conceals retinoid-induced flakiness
Approved for 8 of the 16 Baumann Skin Types.
Key ingredients

Attracts water, giving cells and skin volume. Plays a key role in cell signals and other vital processes. It cushions the skin, providing resilience and firmness. This moisturizing humectant temporarily plumps fine lines and wrinkles. HA makes skin feel dewy and look radiant and glowing. Great for oily skin because it feels lightweight and non-greasy on the skin. Safe for all skin types. HA helps other skincare products get into the skin. This antiaging and hydrating ingredient can radically alter how your skin routine works by affecting penetration and absorption of other ingredients- so make sure you use it in the correct step of your skin care routine.

Sodium Polyglutamate
Sodium Polyglutamate is a potent humectant derived from fermented soybeans, known for its impressive moisture-retention abilities, even surpassing hyaluronic acid (HA) in hydration ability. Some studies have suggested that it inhibits the enzyme hyaluronidase that breaks down HA.

Acetyl Glucosamine
Acetyl Glucosamine is a type of sugar (saccharide) that helps make glycosaminoglycans like hyaluronic acid which keep skin hydrated, and reduce wrinkles. It also helps suppress the production of melanin, the pigment that causes dark spots, making it useful for treating uneven skin tone. Additionally, it has soothing anti-inflammatory effects. it is a humectant.
Full ingredient list
Product type and skin type data
| Brand | Neocutis |
|---|---|
| Product type | Facial Moisturizer |
| Approved Baumann Skin Types | OSPW, OSPT, ORPT, ORNT, OSNW, OSNT, ORPW, ORNW |
| Recommended for these sensitivities | Acne, Redness, Stinging |
Read more from Dr. Baumann
Skincare LibraryBy Dr. Leslie Baumann · 6 min read
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Questions about this product
Answered by Dr. Leslie Baumann, MD, FAAD · Miami, FL · 200+ partner practices
High molecular weight HA forms a protective moisturizing film on the skin’s surface, sealing in moisture to prevent dehydration. Low molecular weight HA penetrates deeply to nourish the extracellular matrix, enhance transdermal absorption, and diminish wrinkle depth for a more youthful appearance.
Mix the Neocutis HYALIS+ Intensive Hydrating Serum on the back of your hand with your eye concealer or your facial foundation. It will help smooth flaking skin so it won't look worse when you apply makeup.
You can use this serum with retinoids, but it will increase absorption and make them more potent- so be careful.
You can apply this right after microneedling, but it will increase absorption of the phenoxyethanol which could cause some irritation if you are sensitive to it. However, it is not easy to find a HA serum that does not have phenoxyethanol.
This Neocutis antiaging cream derives its growth factors from fibroblast cells grown in the lab. These cells were originally derived from circumcised skin taken from a baby.
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